Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress …

MO Meade, DJ Cook, GH Guyatt, AS Slutsky, YM Arabi… - Jama, 2008 - jamanetwork.com
Context Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung
injury and acute respiratory distress syndrome. Instituting additional strategies to open
collapsed lung tissue may further reduce mortality. Objective To compare an established low-
tidal-volume ventilation strategy with an experimental strategy based on the original “open-
lung approach,” combining low tidal volume, lung recruitment maneuvers, and high positive-
end–expiratory pressure. Design and Setting Randomized controlled trial with concealed …