Oxidative damage to nucleic acids in severe emphysema
Background Oxidative stress is a key element in the pathogenesis of emphysema, but
oxidation of nucleic acids has been largely overlooked. The aim of this study was to
investigate oxidative damage to nucleic acids in severe emphysematous lungs. Methods
Thirteen human severe emphysematous lungs, including five with α 1-antitrypsin deficiency
(AATD), were obtained from patients receiving lung transplantation. Control lung tissue was
obtained from non-COPD lungs (n= 8) and donor lungs (n= 8). DNA and RNA oxidation …
oxidation of nucleic acids has been largely overlooked. The aim of this study was to
investigate oxidative damage to nucleic acids in severe emphysematous lungs. Methods
Thirteen human severe emphysematous lungs, including five with α 1-antitrypsin deficiency
(AATD), were obtained from patients receiving lung transplantation. Control lung tissue was
obtained from non-COPD lungs (n= 8) and donor lungs (n= 8). DNA and RNA oxidation …