[HTML][HTML] Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
AR Mensenkamp, MC Jong, H van Goor… - Journal of biological …, 1999 - ASBMB
ApoE-deficient mice on low fat diet show hepatic triglyceride accumulation and a reduced
very low density lipoprotein (VLDL) triglyceride production rate. To establish the role of apoE
in the regulation of hepatic VLDL production, the human APOE3 gene was introduced into
apoE-deficient mice by cross-breeding with APOE3 transgenics (APOE3/apoe−/− mice) or
by adenoviral transduction. APOE3 was expressed in the liver and, to a lesser extent, in
brain, spleen, and lung of transgenic APOE3/apoe−/− mice similar to endogenous apoe …
very low density lipoprotein (VLDL) triglyceride production rate. To establish the role of apoE
in the regulation of hepatic VLDL production, the human APOE3 gene was introduced into
apoE-deficient mice by cross-breeding with APOE3 transgenics (APOE3/apoe−/− mice) or
by adenoviral transduction. APOE3 was expressed in the liver and, to a lesser extent, in
brain, spleen, and lung of transgenic APOE3/apoe−/− mice similar to endogenous apoe …