[HTML][HTML] EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma
B Terris, C Cavard, C Perret - Journal of hepatology, 2010 - Elsevier
Background & Aims: Cancer progression/metastases and embryonic development share
many properties including cellular plasticity, dynamic cell motility, and integral interaction
with the microenvironment. We hypothesized that the heterogeneous nature of
hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer
cells with stem/progenitor features. Methods: Gene expression profiling and
immunohistochemistry analyses were used to analyze 235 tumor specimens derived from 2 …
many properties including cellular plasticity, dynamic cell motility, and integral interaction
with the microenvironment. We hypothesized that the heterogeneous nature of
hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer
cells with stem/progenitor features. Methods: Gene expression profiling and
immunohistochemistry analyses were used to analyze 235 tumor specimens derived from 2 …