Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
M Castro, T Schweiger, H Yin-DeClue… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Immune response after viral infection usually involves TH1-mediated
response; however, severe respiratory syncytial virus (RSV) infection appears to be
associated with the development of asthma, a TH2-predominant phenotype. OBJECTIVE: To
understand the early and subsequent immunologic response to a serious RSV infection in
children over time. METHODS: A total of 206 previously healthy infants hospitalized with
severe RSV bronchiolitis were enrolled in a prospective cohort called the RSV Bronchiolitis …
response; however, severe respiratory syncytial virus (RSV) infection appears to be
associated with the development of asthma, a TH2-predominant phenotype. OBJECTIVE: To
understand the early and subsequent immunologic response to a serious RSV infection in
children over time. METHODS: A total of 206 previously healthy infants hospitalized with
severe RSV bronchiolitis were enrolled in a prospective cohort called the RSV Bronchiolitis …