[HTML][HTML] The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor* 210
Y Luo, C Liang, AR Tall - Journal of Biological Chemistry, 2001 - ASBMB
The human cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high
density lipoproteins to triglyceride-rich lipoproteins, indirectly facilitating cholesteryl esters
uptake by the liver. Hepatic CETP gene expression is increased in response to dietary
hypercholesterolemia, an effect that is mediated by the activity of liver X receptor/retinoid X
receptor (LXR/RXR) on a direct repeat 4 element in the CETPpromoter. In this study we
show that the orphan nuclear receptor LRH-1 also transactivates the CETP promoter by …
density lipoproteins to triglyceride-rich lipoproteins, indirectly facilitating cholesteryl esters
uptake by the liver. Hepatic CETP gene expression is increased in response to dietary
hypercholesterolemia, an effect that is mediated by the activity of liver X receptor/retinoid X
receptor (LXR/RXR) on a direct repeat 4 element in the CETPpromoter. In this study we
show that the orphan nuclear receptor LRH-1 also transactivates the CETP promoter by …