[HTML][HTML] Breast cancer stem cells: eradication by differentiation therapy?
H Beug - Cell, 2009 - cell.com
H Beug
Cell, 2009•cell.comDuring metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to
an epithelial-to-mesenchymal transition (EMT). Gupta et al.(2009) use this attribute of cancer
stem cells to develop a high-throughput screen, which successfully identifies small
molecules that specifically inhibit cancer stem cell proliferation through the induction of
differentiation.
an epithelial-to-mesenchymal transition (EMT). Gupta et al.(2009) use this attribute of cancer
stem cells to develop a high-throughput screen, which successfully identifies small
molecules that specifically inhibit cancer stem cell proliferation through the induction of
differentiation.
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
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