Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study

O Braissant, H Henry, M Loup, B Eilers… - Molecular brain …, 2001 - Elsevier
Creatine is synthesized from arginine by l-arginine: glycine amidinotransferase (AGAT) and
S-adenosyl-l-methionine: N-guanidinoacetate methyltransferase (GAMT) and can be taken
up by cells by creatine transporters (CRT). While creatine is mainly synthesized by the liver
and the kidney, most of other tissues, including the brain, also express AGAT and GAMT.
There is evidence that the permeability of the blood–brain barrier (BBB) for creatine is
limited, suggesting that the brain is dependent on its own creatine synthesis. In order to …