Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation

A Watanabe, N Kato, T Kato - Neuroscience research, 2002 - Elsevier
While the role of creatine in preventing muscle (peripheral) fatigue for high performance
athletes is well understood, its biochemical role in prevention of mental (central) fatigue is
not. Creatine is abundant in muscles and the brain and after phosphorylation used as an
energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled
paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces
mental fatigue when subjects repeatedly perform a simple mathematical calculation. After …