Intracellular Leishmania: your iron or mine?
JF Marquis, P Gros - Trends in microbiology, 2007 - cell.com
JF Marquis, P Gros
Trends in microbiology, 2007•cell.comIron is a co-factor for several essential enzymes and biochemical pathways, including those
required for replication of pathogens such as Leishmania in macrophages. Iron acquisition
is emerging as a key battleground in which the iron import systems of microbes are pitted
against the iron withdrawal and sequestration systems of macrophages, with both competing
for iron at the interface of host–pathogen interaction. The recent characterization of a ferrous
iron transport system (LIT1) in Leishmania amazonensis that is induced intracellularly and is …
required for replication of pathogens such as Leishmania in macrophages. Iron acquisition
is emerging as a key battleground in which the iron import systems of microbes are pitted
against the iron withdrawal and sequestration systems of macrophages, with both competing
for iron at the interface of host–pathogen interaction. The recent characterization of a ferrous
iron transport system (LIT1) in Leishmania amazonensis that is induced intracellularly and is …
Iron is a co-factor for several essential enzymes and biochemical pathways, including those required for replication of pathogens such as Leishmania in macrophages. Iron acquisition is emerging as a key battleground in which the iron import systems of microbes are pitted against the iron withdrawal and sequestration systems of macrophages, with both competing for iron at the interface of host–pathogen interaction. The recent characterization of a ferrous iron transport system (LIT1) in Leishmania amazonensis that is induced intracellularly and is required for survival in macrophages and for virulence in vivo provides an elegant example of the adaptation of protozoa to the iron-poor phagosomal environment.
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