[HTML][HTML] On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake
In this study, we explore the effects of several FOX and mutant FOX transcription factors on
adipocyte determination, differentiation, and metabolism. In addition to Foxc2 and Foxo1, we
report that Foxf2, Foxp1, and Foxa1 are other members of the Fox family that show regulated
expression during adipogenesis. Although enforced expression of FOXC2 inhibits
adipogenesis, Foxf2 slightly enhances the rate of differentiation. Constitutively active FOXC2-
VP16 inhibits adipogenesis through multiple mechanisms. FOXC2-VP16 impairs the …
adipocyte determination, differentiation, and metabolism. In addition to Foxc2 and Foxo1, we
report that Foxf2, Foxp1, and Foxa1 are other members of the Fox family that show regulated
expression during adipogenesis. Although enforced expression of FOXC2 inhibits
adipogenesis, Foxf2 slightly enhances the rate of differentiation. Constitutively active FOXC2-
VP16 inhibits adipogenesis through multiple mechanisms. FOXC2-VP16 impairs the …