[HTML][HTML] Regulation of secreted Frizzled-related protein-1 by heparin
X Zhong, T Desilva, L Lin, P Bodine, RA Bhat… - Journal of Biological …, 2007 - ASBMB
Secreted Frizzled-related protein-1 (sFRP-1) belongs to a class of extracellular antagonists
that modulate Wnt signaling pathways by preventing ligand-receptor interactions among
Wnts and Frizzled membrane receptor complexes. sFRP-1 and Wnts are heparin-binding
proteins, and their interaction can be stabilized by heparin in vitro. Here we report that
heparin can specifically enhance recombinant sFRP-1 accumulation in a cell type-specific
manner. The effect requires O-sulfation in heparin, and involves fibroblast growth factor-2 as …
that modulate Wnt signaling pathways by preventing ligand-receptor interactions among
Wnts and Frizzled membrane receptor complexes. sFRP-1 and Wnts are heparin-binding
proteins, and their interaction can be stabilized by heparin in vitro. Here we report that
heparin can specifically enhance recombinant sFRP-1 accumulation in a cell type-specific
manner. The effect requires O-sulfation in heparin, and involves fibroblast growth factor-2 as …