[PDF][PDF] A second canon: functions and mechanisms of β-catenin-independent Wnt signaling

MT Veeman, JD Axelrod, RT Moon - Developmental cell, 2003 - cell.com
MT Veeman, JD Axelrod, RT Moon
Developmental cell, 2003cell.com
More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and
mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing
questions. How many noncanonical Wnt pathways are there? How extensive are the
parallels between Drosophila planar polarization and vertebrate convergence and
extension? Last, we will outline some challenges and difficulties we foresee for this exciting …
Abstract
More is becoming known about so-called noncanonical Wnt pathways that signal independently of β-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.
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