Production of hydrogen peroxide by peripheral blood monocytes and specific macrophages during experimental infection with Trypanosoma cruzi in vivo
Acute Chagas' disease triggers potent inflammatory reaction characterized by great increase
of peripheral blood monocyte (PBM) and macrophage numbers. We studied the respiratory
burst responses of PBM and peritoneal and splenic macrophages to in vivo infection (rats).
The ultrastructure of heart inflammatory macrophages was also investigated. The infection
increased the hydrogen peroxide (H2O2) production by PBM and splenic macrophages but
not by peritoneal macrophages. Accordingly, the PBM and spleen cell numbers increased …
of peripheral blood monocyte (PBM) and macrophage numbers. We studied the respiratory
burst responses of PBM and peritoneal and splenic macrophages to in vivo infection (rats).
The ultrastructure of heart inflammatory macrophages was also investigated. The infection
increased the hydrogen peroxide (H2O2) production by PBM and splenic macrophages but
not by peritoneal macrophages. Accordingly, the PBM and spleen cell numbers increased …