Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism
MA Muñoz-Fernández, MA Fernández, M Fresno - Immunology letters, 1992 - Elsevier
The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary
resident macrophages, but is killed by activated macrophages. Pretreatment of human
macrophages with recombinant IFN-γ and to a lesser extent with TNF-α, induced a
significant trypanocidal activity. Furthermore, TNF-α had a synergistic effect with IFN-γ on
macrophage activation in T. cruzi killing. Similarly, IFN-γ triggered the production of nitric
oxide (NO) by macrophages, whereas TNF-α was less effective, although it was also …
resident macrophages, but is killed by activated macrophages. Pretreatment of human
macrophages with recombinant IFN-γ and to a lesser extent with TNF-α, induced a
significant trypanocidal activity. Furthermore, TNF-α had a synergistic effect with IFN-γ on
macrophage activation in T. cruzi killing. Similarly, IFN-γ triggered the production of nitric
oxide (NO) by macrophages, whereas TNF-α was less effective, although it was also …