[HTML][HTML] Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses

LYA Chai, AG Vonk, BJ Kullberg, PE Verweij… - Microbes and …, 2011 - Elsevier
Aspergillus fumigatus conidia attenuates host proinflammatory responses through
modulation of Toll-like receptor (TLR) 2 and TLR4 signaling, but the precise mechanisms
that mediate this effect are not known. In the present study, the role of the Aspergillus cell
wall polysaccharide constituents responsible for the modulation of host capability to mount a
proinflammatory response was studied. Aspergillus cell wall fractions and its major
components showed differential capabilities in modulating host TLR-mediated interleukin …