[HTML][HTML] Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
Z Gao, Y Shao, X Jiang - Journal of Biological Chemistry, 2005 - ASBMB
Caspase-2 is an initiating caspase required for stress-induced apoptosis in various human
cancer cells. Recent studies suggest that it can mediate the death function of tumor
suppressor p53 and is activated by a multimeric protein complex, PIDDosome. However, it is
not clear how caspase-2 exerts its apoptotic function in cells and whether its enzymatic
activity is required for the apoptotic function. In this study, we used both in vitro mitochondrial
cytochrome c release assays and cell culture apoptosis analyses to investigate the …
cancer cells. Recent studies suggest that it can mediate the death function of tumor
suppressor p53 and is activated by a multimeric protein complex, PIDDosome. However, it is
not clear how caspase-2 exerts its apoptotic function in cells and whether its enzymatic
activity is required for the apoptotic function. In this study, we used both in vitro mitochondrial
cytochrome c release assays and cell culture apoptosis analyses to investigate the …