[HTML][HTML] Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor: a novel function for a caspase prodomain
PA Colussi, NL Harvey, S Kumar - Journal of Biological Chemistry, 1998 - ASBMB
Caspases are cysteine proteases that play an essential role in apoptosis by cleaving several
key cellular proteins. Despite their function in apoptosis, little is known about where in the
cell they are localized and whether they are translocated to specific cellular compartments
upon activation. In the present paper, usingAequorea victoria green fluorescent protein
fusion constructs, we have determined the localization of Nedd2 (mouse caspase-2) and
show that both precursor and processed caspase-2 localize to the cytoplasmic and the …
key cellular proteins. Despite their function in apoptosis, little is known about where in the
cell they are localized and whether they are translocated to specific cellular compartments
upon activation. In the present paper, usingAequorea victoria green fluorescent protein
fusion constructs, we have determined the localization of Nedd2 (mouse caspase-2) and
show that both precursor and processed caspase-2 localize to the cytoplasmic and the …