[HTML][HTML] Novel NEMO/IκB kinase and NF-κB target genes at the pre-B to immature B cell transition
J Li, GW Peet, D Balzarano, X Li, P Massa… - Journal of Biological …, 2001 - ASBMB
The IκB kinase (IKK) signaling complex is responsible for activating NF-κB-dependent gene
expression programs. Even though NF-κB-responsive genes are known to orchestrate stress-
like responses, critical gaps in our knowledge remain about the global effects of NF-κB
activation on cellular physiology. DNA microarrays were used to compare gene expression
programs in a model system of 70Z/3 murine pre-B cellsversus their IKK signaling-defective
1.3 E2 variant with lipopolysaccharide (LPS), interleukin-1 (IL-1), or a combination of LPS+ …
expression programs. Even though NF-κB-responsive genes are known to orchestrate stress-
like responses, critical gaps in our knowledge remain about the global effects of NF-κB
activation on cellular physiology. DNA microarrays were used to compare gene expression
programs in a model system of 70Z/3 murine pre-B cellsversus their IKK signaling-defective
1.3 E2 variant with lipopolysaccharide (LPS), interleukin-1 (IL-1), or a combination of LPS+ …