The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.

KR Loeb, AL Haas - Journal of Biological Chemistry, 1992 - ASBMB
We have previously identified a 15-kDa interferon-induced protein that is recognized by
affinity-purified rabbit polyclonal antibodies against ubiquitin (Haas, AL, Ahrens, P., Bright,
PM, and Ankel, H.(1987) J. Biol. Chem. 262, 11315-11323). This ubiquitin cross-reactive
protein (UCRP) possesses significant homology to a tandem diubiquitin sequence. Since
the biological effects of ubiquitin arise from its covalent ligation to intracellular target
proteins, we hypothesized that the multiple cellular responses to inteferon are mediated in …