A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
K Kok, R Hofstra, A Pilz… - Proceedings of the …, 1993 - National Acad Sciences
K Kok, R Hofstra, A Pilz, A van den Berg, P Terpstra, CH Buys, B Carritt
Proceedings of the National Academy of Sciences, 1993•National Acad SciencesThe chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We
recently cloned a gene from this region that has greatly reduced expression in almost all
lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor
and nontumor cell types. We report here the sequence of this gene and show that it has
significant homology to the genes encoding the ubiquitin-activating enzymes of three
species, including humans. This suggests it is a second, autosomal member of this gene …
recently cloned a gene from this region that has greatly reduced expression in almost all
lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor
and nontumor cell types. We report here the sequence of this gene and show that it has
significant homology to the genes encoding the ubiquitin-activating enzymes of three
species, including humans. This suggests it is a second, autosomal member of this gene …
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.
National Acad Sciences