Molecular basis for risk factors
RG Hardy, SJ Meltzer, JA Jankowski - Bmj, 2000 - bmj.com
RG Hardy, SJ Meltzer, JA Jankowski
Bmj, 2000•bmj.comEvidence for the molecular basis of colorectal cancer comes from genetic analysis of tissues
either from patients with a family history of the disease or from patients with sporadic
adenomatous colorectal polyps or extensive ulcerative colitis. The traditional view is that
background rates of genetic mutation, combined with several rounds of clonal expansion,
are necessary for a tumour to develop. It has recently been argued, however, that inherent
genetic instability not only is necessary but may also be sufficient for cancer to develop.
either from patients with a family history of the disease or from patients with sporadic
adenomatous colorectal polyps or extensive ulcerative colitis. The traditional view is that
background rates of genetic mutation, combined with several rounds of clonal expansion,
are necessary for a tumour to develop. It has recently been argued, however, that inherent
genetic instability not only is necessary but may also be sufficient for cancer to develop.
Evidence for the molecular basis of colorectal cancer comes from genetic analysis of tissues either from patients with a family history of the disease or from patients with sporadic adenomatous colorectal polyps or extensive ulcerative colitis. The traditional view is that background rates of genetic mutation, combined with several rounds of clonal expansion, are necessary for a tumour to develop. It has recently been argued, however, that inherent genetic instability not only is necessary but may also be sufficient for cancer to develop.
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