[HTML][HTML] Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells
K Evaul, SR Hammes - Journal of Biological Chemistry, 2008 - ASBMB
Gonadal steroid production is stimulated by gonadotropin binding to G protein-coupled
receptors (GPCRs). Although GPCR-mediated increases in intracellular cAMP are known
regulators of steroidogenesis, the roles of other signaling pathways in mediating steroid
production are not well characterized. Recent studies suggest that luteinizing hormone (LH)
receptor activation leads to trans-activation of epidermal growth factor (EGF) receptors in the
testes and ovary. This pathway is critical for LH-induced steroid production in ovarian …
receptors (GPCRs). Although GPCR-mediated increases in intracellular cAMP are known
regulators of steroidogenesis, the roles of other signaling pathways in mediating steroid
production are not well characterized. Recent studies suggest that luteinizing hormone (LH)
receptor activation leads to trans-activation of epidermal growth factor (EGF) receptors in the
testes and ovary. This pathway is critical for LH-induced steroid production in ovarian …