The role of the lipogenic pathway in the development of hepatic steatosis
C Postic, J Girard - Diabetes & metabolism, 2008 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of diseases, ranging
from simple fatty liver (hepatic steatosis) through steatosis with inflammation and necrosis to
cirrhosis. NAFLD, which is strongly associated with obesity, insulin resistance and type 2
diabetes, is now well recognized as being part of the metabolic syndrome. The metabolic
pathways leading to the development of hepatic steatosis are multiple, including enhanced
non-esterified fatty acid release from adipose tissue (lipolysis), increased de novo fatty acids …
from simple fatty liver (hepatic steatosis) through steatosis with inflammation and necrosis to
cirrhosis. NAFLD, which is strongly associated with obesity, insulin resistance and type 2
diabetes, is now well recognized as being part of the metabolic syndrome. The metabolic
pathways leading to the development of hepatic steatosis are multiple, including enhanced
non-esterified fatty acid release from adipose tissue (lipolysis), increased de novo fatty acids …