Aldosterone is currently thought to exert its physiologic effects by activating epithelial
mineralocorticoid receptors, and its pathologic effects on the cardiovascular system via
mineralocorticoid receptors in the heart and blood vessels. Recent studies have extended
this understanding to include a reevaluation of the roles of aldosterone and
mineralocorticoid receptor activation in blood pressure control; the rapid, nongenomic
effects of aldosterone; the role of cortisol as a mineralocorticoid receptor agonist under …