Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia

AK Gupta, P Hasler, W Holzgreve, S Gebhardt… - Human immunology, 2005 - Elsevier
Preeclampsia, a severe pregnancy-related disorder, involves an overt activation of the
maternal innate immune system, proposed to result from the elevated release of
inflammatory syncytiotrophoblast microparticles (STBM) and cytokines from underlying
placental anomaly involving abnormal trophoblast differentiation. Activation of circulating
neutrophils has recently been shown to lead to the generation of fibrous extracellular lattices
containing DNA, termed NETs (neutrophil extracellular traps). Therefore, we examined …