[HTML][HTML] A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Iα gene mediates the liver-specific …
L Jackson-Hayes, S Song, EN Lavrentyev… - Journal of Biological …, 2003 - ASBMB
Carnitine palmitoyltransferase-I (CPT-I) catalyzes the rate-controlling step of fatty acid
oxidation. CPT-I converts long-chain fatty acyl-CoAs to acylcarnitines for translocation
across the mitochondrial membrane. The mRNA levels and enzyme activity of the liver
isoform, CPT-Iα, are greatly increased in the liver of hyperthyroid animals. Thyroid hormone
(T3) stimulates CPT-Iα transcription far more robustly in the liver than in non-hepatic tissues.
We have shown that the thyroid hormone receptor (TR) binds to a thyroid hormone response …
oxidation. CPT-I converts long-chain fatty acyl-CoAs to acylcarnitines for translocation
across the mitochondrial membrane. The mRNA levels and enzyme activity of the liver
isoform, CPT-Iα, are greatly increased in the liver of hyperthyroid animals. Thyroid hormone
(T3) stimulates CPT-Iα transcription far more robustly in the liver than in non-hepatic tissues.
We have shown that the thyroid hormone receptor (TR) binds to a thyroid hormone response …