Role of the integrin αVβ3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress
DR Clemmons, LA Maile, Y Ling, J Yarber… - Growth hormone & IGF …, 2007 - Elsevier
Under usual conditions, the role of IGF-I in vascular cell types is to maintain cellular protein
synthesis and cell size, and even excess IGF-I does not stimulate proliferation. In
pathophysiologic states, such as hyperglycemia, smooth muscle cells (SMC) dedifferentiate
and change their responsiveness to IGF-I. During hyperglycemia IGF-I stimulates both SMC
migration and proliferation. Our laboratory has investigated the molecular mechanism by
which this change is mediated. During hyperglycemia SMC secrete increased …
synthesis and cell size, and even excess IGF-I does not stimulate proliferation. In
pathophysiologic states, such as hyperglycemia, smooth muscle cells (SMC) dedifferentiate
and change their responsiveness to IGF-I. During hyperglycemia IGF-I stimulates both SMC
migration and proliferation. Our laboratory has investigated the molecular mechanism by
which this change is mediated. During hyperglycemia SMC secrete increased …