In vivo expression of IL-12 and IL-13 in atopic dermatitis
Q Hamid, T Naseer, EM Minshall, YL Song… - Journal of allergy and …, 1996 - Elsevier
Previous studies in atopic dermatitis (AD) have shown that acute and chronic skin lesions
are associated with a TH 2-type profile of cytokine expression. IL-12 and IL-13 are recently
described cytokines, which possess TH 1-and TH 2-like actions, respectively. We have used
the technique of in situ hybridization to examine the expression of IL-12 and IL-13
messenger RNA in skin biopsy specimens of acute and chronic skin lesions and uninvolved
skin from patients with AD. When compared with normal control skin, the acute and chronic …
are associated with a TH 2-type profile of cytokine expression. IL-12 and IL-13 are recently
described cytokines, which possess TH 1-and TH 2-like actions, respectively. We have used
the technique of in situ hybridization to examine the expression of IL-12 and IL-13
messenger RNA in skin biopsy specimens of acute and chronic skin lesions and uninvolved
skin from patients with AD. When compared with normal control skin, the acute and chronic …