The Th1/Th2 paradigm and the allograft response
TB Strom, P Roy-Chaudhury, R Manfro… - Current opinion in …, 1996 - Elsevier
TB Strom, P Roy-Chaudhury, R Manfro, XX Xheng, PW Nickerson, K Wood, A Bushell
Current opinion in immunology, 1996•ElsevierAlthough Th1-and Th2-type cytokine profiles have been associated with rejection and
tolerance respectively, this paradigm may not be completely accurate. Instead, recent
studies suggest that there could be a hierarchy of T-cell growth factors with regard to their
ability to block tolerance and induce rejection (rather than a polarized Th1/Th2
demarcation).
tolerance respectively, this paradigm may not be completely accurate. Instead, recent
studies suggest that there could be a hierarchy of T-cell growth factors with regard to their
ability to block tolerance and induce rejection (rather than a polarized Th1/Th2
demarcation).
Although Th1- and Th2-type cytokine profiles have been associated with rejection and tolerance respectively, this paradigm may not be completely accurate. Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation).
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