Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis
K Fuxe, D Marcellino, G Leo, LF Agnati - Current opinion in pharmacology, 2010 - Elsevier
The intramembrane receptor–receptor interactions among GPCRs demonstrated in the
beginning of the 80s in the CNS probably reflect the existence of allosteric mechanisms in
receptor heteromers, and the postulated assemblies of multiple GPCRs coined 'receptor
mosaics' in the early 80s probably represent higher order receptor heteromers, recently
demonstrated with novel biophysical techniques in living cells. The receptor interface in the
GPCR heteromers is beginning to be characterized and in adenosine A2A–dopamine D2 …
beginning of the 80s in the CNS probably reflect the existence of allosteric mechanisms in
receptor heteromers, and the postulated assemblies of multiple GPCRs coined 'receptor
mosaics' in the early 80s probably represent higher order receptor heteromers, recently
demonstrated with novel biophysical techniques in living cells. The receptor interface in the
GPCR heteromers is beginning to be characterized and in adenosine A2A–dopamine D2 …