[HTML][HTML] Paxillin regulates androgen-and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells
A Sen, K O'Malley, Z Wang, GV Raj… - Journal of Biological …, 2010 - ASBMB
Although transcriptional effects of androgens have been extensively studied, mechanisms
regulating transcription-independent (nongenomic) androgen actions are poorly
understood. Previously, we have shown that paxillin, a multidomain adaptor protein, is a
critical regulator of testosterone-induced MAPK-signaling during Xenopus oocyte
maturation. Here we examine the nongenomic effects of dihydrotestosterone (DHT) in
prostate cancer cells, focusing on how paxillin mediates Erk signaling and downstream …
regulating transcription-independent (nongenomic) androgen actions are poorly
understood. Previously, we have shown that paxillin, a multidomain adaptor protein, is a
critical regulator of testosterone-induced MAPK-signaling during Xenopus oocyte
maturation. Here we examine the nongenomic effects of dihydrotestosterone (DHT) in
prostate cancer cells, focusing on how paxillin mediates Erk signaling and downstream …