[HTML][HTML] The role of FKBP5 in cancer aetiology and chemoresistance
L Li, Z Lou, L Wang - British journal of cancer, 2011 - nature.com
L Li, Z Lou, L Wang
British journal of cancer, 2011•nature.comAbstract FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of
immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs
such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other
FKBPs, it also has unique features, especially its role in the regulation of multiple signalling
pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the
recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic …
immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs
such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other
FKBPs, it also has unique features, especially its role in the regulation of multiple signalling
pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the
recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic …
Abstract
FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other FKBPs, it also has unique features, especially its role in the regulation of multiple signalling pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic therapy.
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