[HTML][HTML] Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate

X Chen, L Ren, S Kim, N Carpino, JL Daniel… - Journal of biological …, 2010 - ASBMB
TULA-1 (UBASH3A/STS-2) and TULA-2 (p70/STS-1) represent a novel class of protein-
tyrosine phosphatases. Previous studies suggest that TULA-2 is sequence-selective toward
phosphotyrosyl (Tyr (P)) peptides. In this work the substrate specificity of TULA-1 and-2 was
systematically evaluated by screening a combinatorial Tyr (P) peptide library. Although
TULA-1 showed no detectable activity toward any of the Tyr (P) peptides in the library, TULA-
2 recognizes two distinct classes of Tyr (P) substrates. On the N-terminal side of Tyr (P), the …