Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities

MR Power Coombs, ME Belderbos… - Expert review of anti …, 2011 - Taylor & Francis
Expert review of anti-infective therapy, 2011Taylor & Francis
Adenosine is an endogenous purine metabolite whose concentration in human blood
plasma rises from nanomolar to micromolar concentrations during the inflammatory process.
Leukocytes express seven-transmembrane adenosine receptors whose engagement
modulates Toll-like receptor-mediated cytokine responses, in part via modulation of
intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to
treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine …
Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.
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