Abstract Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is an
autosomal dominant, systemic fibrovascular dysplasia in which telangiectases,
arteriovenous malformations, and aneurysms may be widely distributed throughout the body
vasculature. Major clinical manifestations include: recurrent bleeding from mucosal
telangiectases and arteriovenous malformations; hypoxemia, cerebral embolism, and brain
abscess due to pulmonary arteriovenous fistulas; high-output congestive heart failure and …