Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
R Bertini, M Bianchi, P Ghezzi - The Journal of experimental medicine, 1988 - rupress.org
R Bertini, M Bianchi, P Ghezzi
The Journal of experimental medicine, 1988•rupress.orgTo clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human
and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has
long been known to increase the susceptibility to endotoxin, rendered mice susceptible to
TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally
prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not
by ibuprofen (10 mg/Kg).
and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has
long been known to increase the susceptibility to endotoxin, rendered mice susceptible to
TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally
prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not
by ibuprofen (10 mg/Kg).
To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
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