The role of JNK2 in toxic liver injury

C Liedtke, C Trautwein - Journal of Hepatology, 2006 - Elsevier
Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of
caspase-8 and the mitochondrial death pathway. Wang Y, Singh R, Lefkowitch JH, Rigoli
RM, Czaja MJ. In vitro studies of hepatocytes have implicated over-activation of c-Jun N-
terminal kinase (JNK) signaling as a mechanism of tumor necrosis factor-alpha (TNF)-
induced apoptosis. However, the functional significance of JNK activation and the role of
specific JNK isoforms in TNF-induced hepatic apoptosis in vivo remain unclear. JNK1 and …