[HTML][HTML] Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9
Y Ikehara, SK Ikehara, JC Paulson - Journal of Biological Chemistry, 2004 - ASBMB
Siglec-7 (p70/AIRM) and Siglec-9 are" CD33"-related siglecs expressed on natural killer
(NK) cells and subsets of peripheral T cells. Like other inhibitory NK cell receptors, they
contain immunoglobulin receptor family tyrosine-based inhibitory motifs in their cytoplasmic
domains, and Siglec-7 has been demonstrated to negatively regulate NK cell activation.
Based on reports of the presence of these siglecs on T cells, we sought to determine if they
are capable of modulating T cell receptor (TCR) signaling using Jurkat T cells stably and …
(NK) cells and subsets of peripheral T cells. Like other inhibitory NK cell receptors, they
contain immunoglobulin receptor family tyrosine-based inhibitory motifs in their cytoplasmic
domains, and Siglec-7 has been demonstrated to negatively regulate NK cell activation.
Based on reports of the presence of these siglecs on T cells, we sought to determine if they
are capable of modulating T cell receptor (TCR) signaling using Jurkat T cells stably and …