Gangliosides as regulators of cell membrane organization and functions
S Sonnino, A Prinetti - Sphingolipids as Signaling and Regulatory …, 2010 - Springer
S Sonnino, A Prinetti
Sphingolipids as Signaling and Regulatory Molecules, 2010•SpringerG angliosides, characteristic complex lipids present in the external layer of plasma
membranes, deeply influence the organization of the membrane as a whole and the function
of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral
interaction. Here we discuss the basis for the membrane-organizing potential of
gangliosides, examples of ganglioside-regulated membrane protein complexes and the
mechanisms for the regulation of ganglioside membrane composition.
membranes, deeply influence the organization of the membrane as a whole and the function
of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral
interaction. Here we discuss the basis for the membrane-organizing potential of
gangliosides, examples of ganglioside-regulated membrane protein complexes and the
mechanisms for the regulation of ganglioside membrane composition.
Abstract
Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.
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