[HTML][HTML] Physical proximity and functional association of glycoprotein 1bα and protein-disulfide isomerase on the platelet plasma membrane

JK Burgess, KA Hotchkiss, C Suter… - Journal of Biological …, 2000 - ASBMB
Platelet function is influenced by the platelet thiol-disulfide balance. Platelet activation
resulted in 440% increase in surface protein thiol groups. Two proteins that presented free
thiol (s) on the activated platelet surface were protein-disulfide isomerase (PDI) and
glycoprotein 1bα (GP1bα). PDI contains two active site dithiols/disulfides. The active sites of
26% of the PDI on resting platelets was in the dithiol form, compared with 81% in the dithiol
form on activated platelets. Similarly, GP1bα presented one or more free thiols on the …