[HTML][HTML] Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells
BA Maron, YY Zhang, DE Handy, A Beuve… - Journal of biological …, 2009 - ASBMB
Hyperaldosteronism is associated with impaired endothelium-dependent vascular reactivity
owing to increased reactive oxygen species and decreased bioavailable nitric oxide (NO·);
however, the effects of aldosterone on vasodilatory signaling pathways in vascular smooth
muscle cells (VSMC) remain unknown. Soluble guanylyl cyclase (GC) is a heterodimer that
is activated by NO· to convert cytosolic GTP to cGMP, a second messenger required for
normal VSMC relaxation. Here, we show that aldosterone (10-9-10-7 mol/liter) diminishes …
owing to increased reactive oxygen species and decreased bioavailable nitric oxide (NO·);
however, the effects of aldosterone on vasodilatory signaling pathways in vascular smooth
muscle cells (VSMC) remain unknown. Soluble guanylyl cyclase (GC) is a heterodimer that
is activated by NO· to convert cytosolic GTP to cGMP, a second messenger required for
normal VSMC relaxation. Here, we show that aldosterone (10-9-10-7 mol/liter) diminishes …