[HTML][HTML] Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed toClostridium difficile Toxin A
ML Chen, C Pothoulakis, JT LaMont - Journal of Biological Chemistry, 2002 - ASBMB
Clostridium difficile toxin A increases paracellular permeability in colonic epithelial T84 cells
by mechanisms involving RhoA glucosylation and actin depolymerization. However, we
previously observed that toxin A-mediated decline in transepithelial electrical resistance
preceded changes in cell morphology and tight junction ultrastructure (Hecht, G.,
Pothoulakis, C., LaMont, JT, and Madara, JL (1988) J. Clin. Invest. 82, 1516–1524). Recent
studies also showed thatC. difficile toxins induce early cellular responses, including …
by mechanisms involving RhoA glucosylation and actin depolymerization. However, we
previously observed that toxin A-mediated decline in transepithelial electrical resistance
preceded changes in cell morphology and tight junction ultrastructure (Hecht, G.,
Pothoulakis, C., LaMont, JT, and Madara, JL (1988) J. Clin. Invest. 82, 1516–1524). Recent
studies also showed thatC. difficile toxins induce early cellular responses, including …