Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy.
There is no effective treatment and patients typically die in approximately the third decade.
DMD is an X-linked recessive disease caused by mutations in the dystrophin gene. There
are three mammalian models of DMD that have been used to understand better the
pathogenesis of disease and develop therapeutic strategies. The mdx mouse is the most
widely used model of DMD that displays some features of muscle degeneration, but the …