[HTML][HTML] Protein kinase Cζ mediates cigarette smoke/aldehyde-and lipopolysaccharide-induced lung inflammation and histone modifications
H Yao, J Hwang, J Moscat, MT Diaz-Meco… - Journal of biological …, 2010 - ASBMB
Atypical protein kinase C (PKC) ζ is an important regulator of inflammation through activation
of the nuclear factor-κB (NF-κB) pathway. Chromatin remodeling on pro-inflammatory genes
plays a pivotal role in cigarette smoke (CS)-and lipopolysaccharide (LPS)-induced abnormal
lung inflammation. However, the signaling mechanism whereby chromatin remodeling
occurs in CS-and LPS-induced lung inflammation is not known. We hypothesized that PKCζ
is an important regulator of chromatin remodeling, and down-regulation of PKCζ ameliorates …
of the nuclear factor-κB (NF-κB) pathway. Chromatin remodeling on pro-inflammatory genes
plays a pivotal role in cigarette smoke (CS)-and lipopolysaccharide (LPS)-induced abnormal
lung inflammation. However, the signaling mechanism whereby chromatin remodeling
occurs in CS-and LPS-induced lung inflammation is not known. We hypothesized that PKCζ
is an important regulator of chromatin remodeling, and down-regulation of PKCζ ameliorates …