New paradigms in the pathogenesis of chronic obstructive pulmonary disease I
W MacNee, RM Tuder - Proceedings of the American Thoracic …, 2009 - atsjournals.org
W MacNee, RM Tuder
Proceedings of the American Thoracic Society, 2009•atsjournals.orgThis paper reviews the potential participation of novel pathogenic mechanisms in chronic
obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and
enhanced expression of markers of senescence in emphysematous lungs and the potential
enhanced tissue destruction involving alveolar apoptosis. These insights provide new
beginnings for future investigations in the pathobiology of COPD which may lead to future
therapies for this condition.
obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and
enhanced expression of markers of senescence in emphysematous lungs and the potential
enhanced tissue destruction involving alveolar apoptosis. These insights provide new
beginnings for future investigations in the pathobiology of COPD which may lead to future
therapies for this condition.
This paper reviews the potential participation of novel pathogenic mechanisms in chronic obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and enhanced expression of markers of senescence in emphysematous lungs and the potential enhanced tissue destruction involving alveolar apoptosis. These insights provide new beginnings for future investigations in the pathobiology of COPD which may lead to future therapies for this condition.
ATS Journals