The life cycle of C-myc: from synthesis to degradation

RC Sears - Cell cycle, 2004 - Taylor & Francis
RC Sears
Cell cycle, 2004Taylor & Francis
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate
decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell
function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-
Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a
sophisticated and complex signaling pathway that controls the life cycle of c-Myc from
protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated …
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.
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