Context Various factors are involved in the pathogenesis of schizophrenia. Accumulation of
advanced glycation end products, including pentosidine, results from carbonyl stress, a state
featuring an increase in reactive carbonyl compounds (RCOs) and their attendant protein
modifications. Vitamin B 6 is known to detoxify RCOs, including advanced glycation end
products. Glyoxalase I (GLO1) is one of the enzymes required for the cellular detoxification
of RCOs. Objectives To examine whether plasma levels of pentosidine and serum vitamin B …