Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma
MV Kato, T Shimizu, K Ishizaki, A Kaneko, DW Yandell… - Cancer letters, 1996 - Elsevier
MV Kato, T Shimizu, K Ishizaki, A Kaneko, DW Yandell, J Toguchida, MS Sasaki
Cancer letters, 1996•ElsevierLoss of heterozygosity (LOH) on chromosome 17 and mutations of the p53 gene were
examined in 25 retinoblastomas (RB), consisting of three familial tumors, nine hereditary
tumors without family history, 11 non-hereditary tumors, one recurrent tumor and one lung-
metastatic tumor. LOH on chromosome 17 was detected in only one of the 23 primary RB.
No mutations of the p53 gene were detected in the primary tumors. A recurrent tumor
showed LOH on the short arm region of chromosome 17. LOH on chromosome 17 and a …
examined in 25 retinoblastomas (RB), consisting of three familial tumors, nine hereditary
tumors without family history, 11 non-hereditary tumors, one recurrent tumor and one lung-
metastatic tumor. LOH on chromosome 17 was detected in only one of the 23 primary RB.
No mutations of the p53 gene were detected in the primary tumors. A recurrent tumor
showed LOH on the short arm region of chromosome 17. LOH on chromosome 17 and a …
Loss of heterozygosity (LOH) on chromosome 17 and mutations of the p53 gene were examined in 25 retinoblastomas (RB), consisting of three familial tumors, nine hereditary tumors without family history, 11 non-hereditary tumors, one recurrent tumor and one lung-metastatic tumor. LOH on chromosome 17 was detected in only one of the 23 primary RB. No mutations of the p53 gene were detected in the primary tumors. A recurrent tumor showed LOH on the short arm region of chromosome 17. LOH on chromosome 17 and a point mutation of the p53 gene were also detected in a metastatic tumor. These results suggest that LOH on chromosome 17 and mutation of the p53 gene may not be associated with the development of primary RB, but may play a role in the progression of RB.
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