[HTML][HTML] The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response [S]
Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress.
Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein
response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown
that markers of ER stress/UPR activation, including GRP78, phospho-eIF2α, and spliced
XBP1, are upregulated during adipogenesis. Given these findings, the objective of this study
was to determine whether attenuation of UPR activation by the chemical chaperone 4 …
Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein
response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown
that markers of ER stress/UPR activation, including GRP78, phospho-eIF2α, and spliced
XBP1, are upregulated during adipogenesis. Given these findings, the objective of this study
was to determine whether attenuation of UPR activation by the chemical chaperone 4 …